Genetic variability of hepatitis A virus
نویسندگان
چکیده
منابع مشابه
Genetic variability of hepatitis A virus.
Knowledge of the molecular biology of hepatitis A virus (HAV) has increased exponentially since its identification. HAV exploits all known mechanisms of genetic variation to ensure survival, including mutation and genetic recombination. HAV has been characterized by the emergence of different genotypes, three human antigenic variants and only one major serotype. This paper reviews the genetic v...
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Sequence heterogeneity is a feature of hepatitis B virus (HBV), the prototype member of the family Hepadnaviridae. Based on an intergroup divergence of greater than 7.5% across the complete genome, HBV has been classified phylogenetically into 9 genotypes, A-I, with a putative 10th genotype 'J', isolated from a single individual. With between approximately 4 and 8% intergroup nucleotide diverge...
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Results The mean age of patients was 44 ± 12.2. Most of them were HBeAg negative (90%). The mean HBV DNA was 475104 ± 160591 UI/mL. Phylogenetic analysis identified 90% isolates in genotype D and 10% in genotype A. Most genotypes D isolates belonged to subgenotype D7 (80%) followed by subgenotype D1 (25%) and one isolate belonged to subgenotype D2. All genotype A strains belonged to subgenotype...
متن کاملGenetic variability in hepatitis B viruses.
In 1988, it was reported that the full nucleotide sequences of 18 hepatitis B virus (HBV) strains clustered into four genetic groups (A to D) with more than 8% divergence between the groups. This classification of strains in terms of genome sequence has since proven to be an important tool in the understanding of HBV epidemiology and evolution and has been expanded to include three more genotyp...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2003
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.19532-0